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The suggested dithiol mechanism for the reduction of EcRNR by EcGrx1 comprises a dithiol-disulfide exchange reaction followed by the stepwise reduction of EcGrx1(S 2 ) and EcGrx1(SSG) by two molecules of GSH (Fig

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13 In the CVOTs, GLP-1 RAs were associated with a reduction in new-onset HF among patients with cardiovascular risk factors, but neutral effects were observed on HF events among patients with already diagnosed and stable HF

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